Published: November 23, 2017

An extracellular matrix-related prognostic and predictive indicator for early-stage non-small cell lung cancer (Nature Communications, 23 Nov 2017)

BIGHEART’s Acting Director Professor Lim Chwee Teck and team have been developing a new system for determining prognosis of lung cancer from extracellular matrix (ECM) components which are important regulators of cancer progression.

An extracellular matrix-related prognostic and predictive indicator for early-stage non-small cell lung cancer
Su Bin LIM, Swee Jin TAN, Wan-Teck LIM & Chwee Teck LIM

The prognosis and prediction of adjuvant chemotherapy (ACT) response in early-stage nonsmall cell lung cancer (NSCLC) patients remain poor in this era of personalized medicine. We hypothesize that extracellular matrix (ECM)-associated components could be potential markers for better diagnosis and prognosis due to their differential expression in 1,943 primary NSCLC tumors as compared to 303 normal lung tissues. Here we develop a 29-gene ECM-related prognostic and predictive indicator (EPPI). We validate a robust performance of the EPPI risk scoring system in multiple independent data sets, comprising a total of 2,071 early-stage NSCLC tumors. Patients are stratified according to the universal cutoff score based on the EPPI when applied in the clinical setting; the low-risk group has significantly better survival outcome. The functional EPPI gene set represents a potential genomic tool to improve patient selection in early-stage NSCLC to further derive the best benefits of ACT and prevent unnecessary treatment or ACT-associated morbidity.

Read the Nature Communications article HERE.